In the Translational Bioinformatics Unit (TransBio) we aim to address relevant challenges and bottlenecks in the course of translating basic science research into clinical knowledge. TransBio is a multi-disciplinary team formed by individuals with different combinations of biological, clinical and quantitative knowledge.
TransBio team is located at Navarrabiomed which is a “biomedical research centre of the Government of Navarre that promotes and facilitates the research of public healthcare professionals. Its location in the heart of the Hospital Complex of Navarre encourages close proximity and collaboration between researchers and professionals working in clinical and healthcare environments”. TransBio has long-term established collaborations with teams at Karolinska Institutet, King´s College London and KAUST.
Recent publications of interest (see the entire list here):
- Joshi et al. Phosphatase inhibitor PPP1R11 modulates resistance of human T cells toward Treg‐mediated suppression of cytokine expression. J Leukoc Biol. 2019.
- Karlsson L, Barbaro M, Ewing E, Gomez-Cabrero D*, Lajic S*; Epigenetic Alterations Associated With Early Prenatal Dexamethasone Treatment, Journal of the Endocrine Society, 2019; 3:1 pp. 250–263.
- Kular et al, DNA methylation as a mediator of HLA-DRB1*15:01 and a protective variant in Multiple Sclerosis. Nat. Communications, 2018; 9 article number 2397.
- Schmidt, A. et al. Time-resolved transcriptome and proteome landscape of human regulatory T cell (Treg ) differentiation reveals novel regulators of FOXP3. BMC Biology. 2018; 16:47 pp.1–35.
- James T, Linde M, Morikawa H, Fernandes SJ, Ruhrmann S, Huss M, …, Gomez-Cabrero D*, Kockum I*. Impact of genetic risk loci for multiple sclerosis on expression of proximal genes in patients. Hum Mol Genet. 2018;0: 1–17. doi:10.1093/hmg/ddy001
- Tényi Á, Cano I, Marabita F, Kiani N, Kalko SG, Barreiro E, …, Gomez-Cabrero D*, Roca J*. Network modules uncover mechanisms of skeletal muscle dysfunction in COPD patients. J Transl Med. BioMed Central; 2018;16: 34. doi:10.1186/s12967-018-1405-y